Higher levels of vitamin D and/or increased exposure to the sun light has partnered with little of a wide variety of conditions including cardiovascular disease, autoimmune disease (disease where the immune system reacts against the tissues of the body, as in type 1 diabetes, multiple sclerosis, rheumatoid arthritis) risk and various forms of cancer. However, the associations not prove causality. For example, it is possible that individuals with higher levels of vitamin D which they enter the Sun more often are essentially healthier and more likely to be free of the disease than those who do not leave much.
It was essentially this point that was made in an editorial in the archives of Internal Medicine [1] .the authors of this study wrote:
"... it seems intuitively unlikely that a single hormone could play an important role in preventing or alleviating the diverse range of diseases that have been linked to low levels of vitamin D."A more plausible and prose for the conclusions of the observational studies of vitamin D explanation is the presence of coincidences common. levels of vitamin D are directly related to exposure to sunlight and physical activity and inversely associated with adiposity. It is likely that less healthy individuals, who are more likely to experience subsequently morbid events, will be heavier, less active, and most deprived of sunlight to the healthier and therefore have lower levels of 25 (OH) D [vitamin D] "."
This can or cannot be cierto.Sin however, a fact which supports the idea that vitamin D can directly affect risk of disease is that vitamin D receptor widely exist around the body, including the adipose tissue, adrenal gland, bone, brain, breast, cartilage, colon, hair follicles, intestine, skeletal muscle (muscle attached to bones, such as the legs and arms), cardiac muscle (heart), kidney, liver, ovarian, pituitary gland, retina, sperm, thyroid and uterus (womb). The importance of this? Well, the presence of a recipient of a substance in a tissue is usually one track quite well to the fact that this substance exerts no influence over the structure or function of that tissue.
A study published this week adds to evidence that vitamin D could directly affect health and risk of disease [2]. This research looked at the link of vitamin D in the DNA of cells. The study found vitamin D had the ability to bind to almost 3000 sites of DNA.Also had the ability to affect the activity of 229 genes, partners with multiple sclerosis, Crohn's disease and diabetes type 1 - all conditions that the risk of that is linked to vitamin D levels and exposure to the Sun.
Interestingly, the study found instances where vitamin D joins genes more commonly found in Europe or Asia (as opposed to, say, Africa) decent. why could it be?Some have suggested an evolutionary explanation.When our ancestors migrated out of Africa to other parts of the world, would reduce the exposure to the Sun, and would therefore D.Bajos vitamin levels vitamin D levels may have lead to bone of issues, including a more narrow pelvis and channel of labour for women, which reduces the chances of success of the reproduction. However, those with a genetic composition made better use of any provision of vitamin D could be less prone to this and is more likely to pass their genes to the next generation.
This most recent investigation together with our knowledge in which binds vitamin D for virtually every tissue in the body, provides very good evidence that this substance has a direct and important role in health and disease.Links between higher levels of vitamin D and/or the display of sunlight appear might at least in part, to the fact that healthy people, more in shape are more likely to go to the Sun.However, this seems to be away from the full story.
References:
1.?A gray, et to the.Vitamin D - a place in the Sun? Arch Intern med 2010; 170 (13): 1099-1100
2 SV, ChIP-following al.Un et Ramagopalan definition the entire genome of vitamin d receptor binding map associations with the disease and the evolving. genome RES 2010 August 24.[EPub ahead of print]
Print this post
No comments:
Post a Comment